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Article

Deletion of the mouse glycine transporter 2 results in a hyperekplexia phenotype and postnatal lethality.

Neuron - 13 Nov 2003

Gomeza Jesús, Ohno Koji, Hülsmann Swen, Armsen Wencke, Eulenburg Volker, Richter Diethelm W, Laube Bodo, Betz Heinrich

Abstract excerpt

The glycine transporter subtype 2 (GlyT2) is localized in the axon terminals of glycinergic neurons. Mice deficient in GlyT2 are normal at birth but during the second postnatal week develop a lethal neuromotor deficiency that resembles severe forms of human hyperekplexia (hereditary startle disease) and is characterized by spasticity, tremor, and an inability to right. Histological and immunological analyses...

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Identifiers

PMID: 14622583
DOI: 10.1016/s0896-6273(03)00673-1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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