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Article

Neurexin and neuroligin mediate retrograde synaptic inhibition in C. elegans.

Science (New York, N.Y.) - 24 Aug 2012

Hu Zhitao, Hom Sabrina, Kudze Tambudzai, Tong Xia-Jing, Choi Seungwon, Aramuni Gayane, Zhang Weiqi, Kaplan Joshua M

Abstract excerpt

The synaptic adhesion molecules neurexin and neuroligin alter the development and function of synapses and are linked to autism in humans. Here, we found that Caenorhabditis elegans neurexin (NRX-1) and neuroligin (NLG-1) mediated a retrograde synaptic signal that inhibited neurotransmitter release at neuromuscular junctions. Retrograde signaling was induced in mutants lacking a muscle microRNA (miR-1) and was...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 22859820
DOI: 10.1126/science.1224896
PMCID: PMC3791080

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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