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Article

Genetic ablation of VIAAT in glycinergic neurons causes a severe respiratory phenotype and perinatal death.

Brain structure & function - 1 Sept 2015

Rahman Jamilur, Besser Stefanie, Schnell Christian, Eulenburg Volker, Hirrlinger Johannes, Wojcik Sonja M, Hülsmann Swen

Abstract excerpt

Both glycinergic and GABAergic neurons require the vesicular inhibitory amino acid transporter (VIAAT) for synaptic vesicle filling. Presynaptic GABA concentrations are determined by the GABA-synthesizing enzymes glutamate decarboxylase (GAD)65 and GAD67, whereas the presynaptic glycine content depends on the plasma membrane glycine transporter 2 (GlyT2). Although severely impaired, glycinergic transmission is...

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Identifiers

PMID: 25027639
DOI: 10.1007/s00429-014-0829-2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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