Article
The physiological roles of vesicular GABA transporter during embryonic development: a study using knockout mice.
Molecular brain - 30 Dec 2010
Saito Kenzi, Kakizaki Toshikazu, Hayashi Ryotaro, Nishimaru Hiroshi, Furukawa Tomonori, Nakazato Yoichi, Takamori Shigeo, Ebihara Satoe, Uematsu Masakazu, Mishina Masayoshi, Miyazaki Jun-ichi, Yokoyama Minesuke, Konishi Shiro, Inoue Koichi, Fukuda Atsuo, Fukumoto Manabu, Nakamura Kenji, Obata Kunihiko, Yanagawa Yuchio
Abstract excerpt
BACKGROUND: The vesicular GABA transporter (VGAT) loads GABA and glycine from the neuronal cytoplasm into synaptic vesicles. To address functional importance of VGAT during embryonic development, we generated global VGAT knockout mice and analyzed them. RESULTS: VGAT knockouts at embryonic day (E) 18.5 exhibited substantial increases in overall GABA and glycine, but not glutamate, contents in the forebrain....
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