Article
Dual role of miR-21 in CD4+ T-cells: activation-induced miR-21 supports survival of memory T-cells and regulates CCR7 expression in naive T-cells.
PloS one - 1 Jan 2013
Smigielska-Czepiel Katarzyna, van den Berg Anke, Jellema Pytrick, Slezak-Prochazka Izabella, Maat Henny, van den Bos Hilda, van der Lei Roelof Jan, Kluiver Joost, Brouwer Elisabeth, Boots Anne Mieke H, Kroesen Bart-Jan
Abstract excerpt
Immune cell-type specific miRNA expression patterns have been described but the detailed role of single miRNAs in the function of T-cells remains largely unknown. We investigated the role of miR-21 in the function of primary human CD4+ T-cells. MiR-21 is substantially expressed in T-cells with a...
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