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Zoonotic orthopoxviruses encode a high-affinity antagonist of NKG2D

4 Jun 2007

Abstract excerpt

NK and T lymphocytes express both activating and inhibiting receptors for various members of the major histocompatibility complex class I superfamily (MHCISF). To evade immunologic cytotoxicity, many viruses interfere with the function of these receptors, generally by altering the displayed profile of MHCISF proteins on host cells. Using a structurally constrained hidden Markov model, we discovered an...

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PMID: 17548517
DOI: 10.1084/jem.20062026

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