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Structural and Functional Characterization of a Fish Type I Subgroup d IFN Reveals Its Binding to Receptors

12 Feb 2024

Abstract excerpt

Teleost fish type I IFNs and the associated receptors from the cytokine receptor family B (CRFB) are characterized by remarkable diversity and complexity. How the fish type I IFNs bind to their receptors is still not fully understood. In this study, we demonstrate that CRFB1 and CRFB5 constitute the receptor pair through which type I subgroup d IFN (IFNd) from large yellow croaker, Larimichthys crocea, activates...

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PMID: 38345351
DOI: 10.4049/jimmunol.2300651

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