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Article

Human Tetherin Exerts Strong Selection Pressure on the HIV-1 Group N Vpu Protein

20 Dec 2012

Abstract excerpt

HIV-1 groups M and N emerged within the last century following two independent cross-species transmissions of SIVcpz from chimpanzees to humans. In contrast to pandemic group M strains, HIV-1 group N viruses are exceedingly rare, with only about a dozen infections identified, all but one in individuals from Cameroon. Poor adaptation to the human host may be responsible for this limited spread of HIV-1 group N in...

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PMID: 23308067
DOI: 10.1371/journal.ppat.1003093

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