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Article

DOA1/UFD3 plays a role in sorting ubiquitinated membrane proteins into multivesicular bodies.

The Journal of biological chemistry - 1 Aug 2008

Ren Jihui, Pashkova Natasha, Winistorfer Stanley, Piper Robert C

Abstract excerpt

Ubiquitin (Ub) is a sorting signal that targets integral membrane proteins to the interior of the vacuole/lysosome by directing them into lumenal vesicles of multivesicular bodies (MVBs). The Vps27-Hse1 complex, which is homologous to the Hrs-STAM complex in mammalian cells, serves as a Ub-sortin...

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Identifiers

PMID: 18508771
DOI: 10.1074/jbc.M802982200
PMCID: PMC2490793

Genes

STAM

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-18508771-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

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DOA1/UFD3 plays a role in sorting ubiquitinated membrane proteins into multivesicular bodies.PMID 18508771Read ↗

Inactivation of the VID27 gene prevents suppression of the doa4 degradation defect in doa4Δ did3Δ double mutant.Semantic proximity Read ↗

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The Vps27/Hse1 complex is a GAT domain-based scaffold for ubiquitin-dependent sorting.Semantic proximity Read ↗

Bro1 coordinates deubiquitination in the multivesicular body pathway by recruiting Doa4 to endosomes.Semantic proximity Read ↗

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