Class I and class II lysyl-tRNA synthetase mutants and the genetic encoding of pyrrolysine in Methanosarcina spp.

doi:10.1111/j.1365-2958.2007.05740.x

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Article

Class I and class II lysyl-tRNA synthetase mutants and the genetic encoding of pyrrolysine in Methanosarcina spp.

Molecular microbiology - 1 Jun 2007

Mahapatra Anirban, Srinivasan Gayathri, Richter Kerstin B, Meyer Andrew, Lienard Tanja, Zhang Jun Kai, Zhao Gang, Kang Patrick T, Chan Michael, Gottschalk Gerhard, Metcalf William W, Krzycki Joseph A

Abstract excerpt

Methanosarcina spp. begin methanogenesis from methylamines with methyltransferases made via the translation of UAG as pyrrolysine. In vitro evidence indicates two possible routes to pyrrolysyl-tRNA(Pyl). PylS ligates pyrrolysine to tRNA(Pyl). Alternatively, class I and class II lysyl-tRNA synthetases (LysRS1 and LysRS2) together form lysyl-tRNA(Pyl), a potential intermediate to pyrrolysyl-tRNA(Pyl). The unusual...

Topics

Chemoautotrophic Growth
Lysine
Lysine-tRNA Ligase
Methanosarcina
Mutation

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Identifiers

PMID: 17542922
DOI: 10.1111/j.1365-2958.2007.05740.x

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