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Article

Reducing the genetic code induces massive rearrangement of the proteome.

Proceedings of the National Academy of Sciences of the United States of America - 2 Dec 2014

O'Donoghue Patrick, Prat Laure, Kucklick Martin, Schäfer Johannes G, Riedel Katharina, Rinehart Jesse, Söll Dieter, Heinemann Ilka U

Abstract excerpt

Expanding the genetic code is an important aim of synthetic biology, but some organisms developed naturally expanded genetic codes long ago over the course of evolution. Less than 1% of all sequenced genomes encode an operon that reassigns the stop codon UAG to pyrrolysine (Pyl), a genetic code variant that results from the biosynthesis of Pyl-tRNA(Pyl). To understand the selective advantage of genetically...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 25404328
DOI: 10.1073/pnas.1420193111
PMCID: PMC4260545

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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