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Article

Cysteinyl-tRNA synthetase is not essential for viability of the archaeon Methanococcus maripaludis.

Proceedings of the National Academy of Sciences of the United States of America - 4 Dec 2001

Stathopoulos C, Kim W, Li T, Anderson I, Deutsch B, Palioura S, Whitman W, Söll D

Abstract excerpt

The methanogenic archaea Methanocaldococcus jannaschii and Methanothermobacter thermautotrophicus contain a dual-specificity prolyl-tRNA synthetase (ProCysRS) that accurately forms both prolyl-tRNA (Pro-tRNA) and cysteinyl-tRNA (Cys-tRNA) suitable for in vivo translation. This intriguing enzyme may even perform its dual role in organisms that possess a canonical single-specificity cysteinyl-tRNA synthetase...

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PMID: 11717392
DOI: 10.1073/pnas.201540498
PMCID: PMC64675

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