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Article

Excision of the Frt-flanked neo (R) cassette from the CD19cre knock-in transgene reduces Cre-mediated recombination.

Transgenic research - 1 Oct 2007

Schmidt-Supprian Marc, Wunderlich F Thomas, Rajewsky Klaus

Abstract excerpt

Intercross of mice transgenic for Flp-recombinase with the CD19cre mouse strain leads to excision of the Frt-flanked neo (R) cassette from the CD19cre knock-in transgene. This significantly reduces the expression level of Cre by the CD19cre transgene and consequently decreases the extent of Cre-mediated recombination of loxP-flanked alleles, most likely due to the fact that this neo (R) cassette contains polyoma...

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Source

Identifiers

PMID: 17541717
DOI: 10.1007/s11248-007-9100-4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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