Article
Removal of the floxed neo gene from a conditional knockout allele by the adenoviral Cre recombinase in vivo.
Genesis (New York, N.Y. : 2000) - 1 Nov 2001
Kaartinen V, Nagy A
Abstract excerpt
Conditional and tissue specific gene targeting using the Cre-loxP recombination system in combination with established ES cell techniques has become a standard for in vivo loss of function studies. In a typical flox and delete gene targeting strategy, the loxP-neo-loxP cassette is inserted into an intron and an additional loxP site is located in one of the homology arms so that loxP sites surround a functionally...
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