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RamA, a Transcriptional Regulator, and AcrAB, an RND-Type Efflux Pump, are Associated with Decreased Susceptibility to Tigecycline in <i>Enterobacter cloacae</i>

1 Mar 2007

Abstract excerpt

Tigecycline, a novel broad-spectrum glycylcycline antibiotic, is active against many gram-positive and gram-negative bacterial pathogens including most strains of Enterobacter cloacae. Recently, however, a few clinical strains of E. cloacae with decreased susceptibility to tigecycline were isolated. In this study, two tigecycline-susceptible mutants of E. cloacae, GC7696 and GC7697, were obtained by transposon...

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Identifiers

PMID: 17536927
DOI: 10.1089/mdr.2006.9990

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RamA, a Transcriptional Regulator, and AcrAB, an RND-Type Efflux Pump, are Associated with Decreased Susceptibility to Tigecycline in <i>Enterobacter cloacae</i>PMID 17536927Read ↗

Emergence of AcrAB-mediated tigecycline resistance in a clinical isolate of Enterobacter cloacae during ciprofloxacin treatment.Semantic proximity Read ↗

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Mechanisms of Tigecycline Resistance among Klebsiella pneumoniae Clinical IsolatesSemantic proximity Read ↗

Tigecycline Efflux as a Mechanism for Nonsusceptibility in <i>Acinetobacter baumannii</i>Semantic proximity Read ↗

RamA upregulates multidrug resistance efflux pumps AcrAB and OqxAB in Klebsiella pneumoniae.Semantic proximity Read ↗

RamA Is an Alternate Activator of the Multidrug Resistance Cascade in Enterobacter aerogenesSemantic proximity Read ↗

AcrAB efflux pump plays a role in decreased susceptibility to tigecycline in Morganella morganii.Semantic proximity Read ↗

Worldwide Disseminated <i>armA</i> Aminoglycoside Resistance Methylase Gene Is Borne by Composite Transposon Tn <i>1548</i>Semantic proximity Read ↗

Novel tigecycline resistance mechanisms in Acinetobacter baumannii mediated by mutations in adeS, rpoB and rrf.Semantic proximity Read ↗

ramR mutations involved in efflux-mediated multidrug resistance in Salmonella enterica serovar Typhimurium.Semantic proximity Read ↗

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