Article
ramR mutations in clinical isolates of Klebsiella pneumoniae with reduced susceptibility to tigecycline.
Antimicrobial agents and chemotherapy - 1 Jun 2010
Hentschke M, Wolters M, Sobottka I, Rohde H, Aepfelbacher M
Abstract excerpt
Five Klebsiella pneumoniae isolates with reduced susceptibility to tigecycline (MIC, 2 microg/ml) were analyzed. A gene homologous to ramR of Salmonella enterica was identified in Klebsiella pneumoniae. Sequencing of ramR in the nonsusceptible Klebsiella strains revealed deletions, insertions, and point mutations. Transformation of mutants with wild-type ramR genes, but not with mutant ramR genes, restored...
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