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Article

Tigecycline Efflux as a Mechanism for Nonsusceptibility in <i>Acinetobacter baumannii</i>

10 Apr 2007

Abstract excerpt

Tigecycline has an extended spectrum of in vitro antimicrobial activities, including that against multidrug-resistant Acinetobacter. After identifying bloodstream isolates of Acinetobacter with reduced susceptibilities to tigecycline, we performed a study to assess tigecycline efflux mediated by the resistance-nodulation-division-type transporter AdeABC. After exposure of two tigecycline-nonsusceptible isolates...

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PMID: 17420217
DOI: 10.1128/aac.01198-06

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