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Article

AcrAB efflux pump plays a role in decreased susceptibility to tigecycline in Morganella morganii.

Antimicrobial agents and chemotherapy - 1 Feb 2005

Ruzin Alexey, Keeney David, Bradford Patricia A

Abstract excerpt

Transposon mutagenesis of a clinical isolate of Morganella morganii, G1492 (tigecycline MIC of 4 microg/ml), yielded two insertion knockout mutants for which tigecycline MICs were 0.03 microg/ml. Transposon insertions mapped to acrA, which is constitutively overexpressed in G1492, suggesting a role of the AcrAB efflux pump in decreased susceptibility to tigecycline in M. morganii.

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Identifiers

PMID: 15673770
DOI: 10.1128/AAC.49.2.791-793.2005
PMCID: PMC547285

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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