Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

RamA upregulates multidrug resistance efflux pumps AcrAB and OqxAB in Klebsiella pneumoniae.

International journal of antimicrobial agents - 1 Feb 2021

Xu Qingqing, Sheng Zike, Hao Min, Jiang Jianping, Ye Meiping, Chen Yijian, Xu Xiaogang, Guo Qinglan, Wang Minggui

Abstract excerpt

Overexpression of the acrAB genes regulated by RamA and overexpression of oqxAB regulated by RarA have been reported to mediate multidrug resistance in Gram-negative bacilli. In this study, regulation of acrAB and oqxAB simultaneously by the global regulator RamA was investigated in a multidrug-resistant Klebsiella pneumoniae clinical isolate (KP22) resistant to tigecycline and other antimicrobials. KP22...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Drug Resistance, Multiple, Bacterial
Share to Genes, Bacterial

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Klebsiella Infections

Share to Klebsiella pneumoniae

Share to Membrane Transport Proteins

Share to Microbial Sensitivity Tests

Share to Tigecycline

Share to Up-Regulation

Source

Identifiers

PMID: 33259915
DOI: 10.1016/j.ijantimicag.2020.106251

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

RamA upregulates multidrug resistance efflux pumps AcrAB and OqxAB in Klebsiella pneumoniae.PMID 33259915Read ↗

Influence of transcriptional activator RamA on expression of multidrug efflux pump AcrAB and tigecycline susceptibility in Klebsiella pneumoniae.Semantic proximity Read ↗

Tigecycline Susceptibility and the Role of Efflux Pumps in Tigecycline Resistance in KPC-Producing Klebsiella pneumoniaeSemantic proximity Read ↗

RamA Is an Alternate Activator of the Multidrug Resistance Cascade in Enterobacter aerogenesSemantic proximity Read ↗

Mechanisms of Tigecycline Resistance among Klebsiella pneumoniae Clinical IsolatesSemantic proximity Read ↗

Genetic regulation of the ramA locus and its expression in clinical isolates of Klebsiella pneumoniaeSemantic proximity Read ↗

ramR mutations involved in efflux-mediated multidrug resistance in Salmonella enterica serovar Typhimurium.Semantic proximity Read ↗

ramR mutations in clinical isolates of Klebsiella pneumoniae with reduced susceptibility to tigecycline.Semantic proximity Read ↗

Roles of ramR and tet(A) Mutations in Conferring Tigecycline Resistance in Carbapenem-Resistant Klebsiella pneumoniae Clinical Isolates.Semantic proximity Read ↗

Multidrug resistance in Klebsiella pneumoniae: a novel gene, ramA, confers a multidrug resistance phenotype in Escherichia coli.Semantic proximity Read ↗

In vitro selection of ramR and soxR mutants overexpressing efflux systems by fluoroquinolones as well as cefoxitin in Klebsiella pneumoniae.Semantic proximity Read ↗

Differential gene expression by RamA in ciprofloxacin-resistant Salmonella Typhimurium.Semantic proximity Read ↗

Differential impact of ramRA mutations on both ramA transcription and decreased antimicrobial susceptibility in Salmonella Typhimurium.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.