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Mechanisms of Tigecycline Resistance among Klebsiella pneumoniae Clinical Isolates

3 Sept 2014

Abstract excerpt

Of 26 tigecycline-nonsusceptible Klebsiella pneumoniae (TNSKP) clinical isolates, 25 had nonsynonymous mutations in ramR and/or acrR (23 in ramR and 10 in acrR). Eight TNSKP isolates possessed overexpression of ramA, acrB, rarA, and oqxB simultaneously, while 8 and 1 TNSKP strains had upregulation of ramA and acrB and of rarA and oqxB, respectively. Thus, resistance mechanisms of 9 TNSKP isolates cannot be...

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PMID: 25182649
DOI: 10.1128/aac.03808-14

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