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Article

Tumor suppression in the absence of p53-mediated cell-cycle arrest, apoptosis, and senescence.

Cell - 8 Jun 2012

Li Tongyuan, Kon Ning, Jiang Le, Tan Minjia, Ludwig Thomas, Zhao Yingming, Baer Richard, Gu Wei

Abstract excerpt

Cell-cycle arrest, apoptosis, and senescence are widely accepted as the major mechanisms by which p53 inhibits tumor formation. Nevertheless, it remains unclear whether they are the rate-limiting steps in tumor suppression. Here, we have generated mice bearing lysine to arginine mutations at one (p53(K117R)) or three (p53(3KR); K117R+K161R+K162R) of p53 acetylation sites. Although p53(K117R/K117R) cells are...

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Identifiers

PMID: 22682249
DOI: 10.1016/j.cell.2012.04.026
PMCID: PMC3688046

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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