Article
p53 is required for radiation-induced apoptosis in mouse thymocytes.
Nature - 29 Apr 1993
Lowe S W, Schmitt E M, Smith S W, Osborne B A, Jacks T
Abstract excerpt
The p53 tumour suppressor gene is the most widely mutated gene in human tumorigenesis. p53 encodes a transcriptional activator whose targets may include genes that regulate genomic stability, the cellular response to DNA damage, and cell-cycle progression. Introduction of wild-type p53 into cell lines that have lost endogenous p53 function can cause growth arrest or induce a process of cell death known as...
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