Article

A Long Lost Key Opens an Ancient Lock: <i>Drosophila</i> Myb Causes a Synthetic Multivulval Phenotype in Nematodes

2019-10-01

Abstract excerpt

<h4>ABSTRACT</h4> The five-protein MuvB core complex (LIN9/Mip130, LIN37/Mip40, LIN52, LIN54/Mip120, and LIN53/p55CAF1/RBBP4) has been highly conserved during the evolution of animals. This nuclear complex interacts with proteins encoded by the RB tumor suppressor gene family and its associated E2F-DP transcription factors to form DREAM complexes that repress the expression of genes that regulate cell cycle prog...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 238f8c60-c358-59ec-9b36-ccaefe5018d5
DOI: 10.1101/788265

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

A Long Lost Key Opens an Ancient Lock: <i>Drosophila</i> Myb Causes a Synthetic Multivulval Phenotype in NematodesDOI 10.1101/788265Read

A long lost key opens an ancient lock: Drosophila Myb causes a synthetic multivulval phenotype in nematodes.Semantic proximity Read

DREAM Interrupted: Severing LIN-35-MuvB association in <i>Caenorhabditis elegans</i> impairs DREAM function but not its chromatin localizationSemantic proximity Read

Some C. elegans class B synthetic multivulva proteins encode a conserved LIN-35 Rb-containing complex distinct from a NuRD-like complex.Semantic proximity Read

C. elegans ISWI and NURF301 antagonize an Rb-like pathway in the determination of multiple cell fates.Semantic proximity Read

Evolutionarily conserved multisubunit RBL2/p130 and E2F4 protein complex represses human cell cycle-dependent genes in quiescence.Semantic proximity Read

DREAM interrupted: severing LIN-35-MuvB association in Caenorhabditis elegans impairs DREAM function but not its chromatin localization.Semantic proximity Read

Caenorhabditis elegans lin-13, a member of the LIN-35 Rb class of genes involved in vulval development, encodes a protein with zinc fingers and an LXCXE motif.Semantic proximity Read

lin-35 and lin-53, two genes that antagonize a C. elegans Ras pathway, encode proteins similar to Rb and its binding protein RbAp48.Semantic proximity Read

Loss of the Caenorhabditis elegans pocket protein LIN-35 reveals MuvB's innate function as the repressor of DREAM target genes.Semantic proximity Read

<i>C. elegans</i> synMuv B proteins regulate spatial and temporal chromatin compaction during developmentSemantic proximity Read

Mutation of the Drosophila homologue of the Myb protooncogene causes genomic instability.Semantic proximity Read

LIN-15B promotes enrichment of H3K9me2 on the promoters of a subset of germline genes that are repressed in somatic cells in C. elegansSemantic proximity Read