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Article

Motor behavioral and neuropathological deficits in mice deficient for normal prion protein expression.

Biochimica et biophysica acta - 1 Jun 2007

Nazor Karah E, Seward Tanya, Telling Glenn C

Abstract excerpt

It has been difficult to reconcile the absence of pathology and apparently normal behavior of mice lacking prion protein (PrP), referred to as Prnp(0/0) mice, with a mechanism of prion pathogenesis involving progressive loss of PrP(C)-mediated neuroprotection. However, here we report that Prnp(0/0) mice exhibit significant age-related defects in motor coordination and balance compared with mice expressing wild...

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Identifiers

PMID: 17531449
DOI: 10.1016/j.bbadis.2007.04.004
PMCID: PMC3025296

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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