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Article

Dissociation of genotype-dependent cognitive and motor behavior in a strain of aging mice devoid of the prion protein.

Behavioural brain research - 6 Aug 2021

Janner Daiane R, de Lima Emanuelle V, da Silva Rachel T, Clarke Julia R, Linden Rafael

Abstract excerpt

The prion glycoprotein (PrPC) is highly expressed in the nervous system as well as in other organs. Its functional roles in behavior have been examined mainly in non co-isogenic, wild-type and PrPC-deficient mice, which showed both age- and genotype-dependent differences. In general, however, effects of genetic background upon behavioral tests are mostly unclear when applied to aging rodents. The present study...

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Identifiers

PMID: 34052264
DOI: 10.1016/j.bbr.2021.113386

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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