Article
Similar target, different effects: late-onset ataxia and spatial learning in prion protein-deficient mouse lines.
Neurogenetics - 1 Oct 2001
Valenti P, Cozzio A, Nishida N, Wolfer D P, Sakaguchi S, Lipp H P
Abstract excerpt
Several lines of mice with targeted deletion of the prion protein gene (Prnp) have been produced, some of them appearing phenotypically normal, others developing late-onset ataxia. This has been tentatively attributed to the size of the targeted deletion in the Prnp gene. but a masking role of genetic background could not be excluded. Thus, we have crossed an ataxic mutant line with large deletion of Prnp (Ngsk...
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