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Article

Truncated prion protein and Doppel are myelinotoxic in the absence of oligodendrocytic PrPC.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 11 May 2005

Radovanovic Ivan, Braun Nathalie, Giger Olivier T, Mertz Kirsten, Miele Gino, Prinz Marco, Navarro Beatriz, Aguzzi Adriano

Abstract excerpt

The cellular prion protein PrP(C) confers susceptibility to transmissible spongiform encephalopathies, yet its normal function is unknown. Although PrP(C)-deficient mice develop and live normally, expression of amino proximally truncated PrP(C) (DeltaPrP) or of its structural homolog Doppel (Dpl) causes cerebellar degeneration that is prevented by coexpression of full-length PrP(C). We now report that mice...

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Identifiers

PMID: 15888663
DOI: 10.1523/JNEUROSCI.0328-05.2005
PMCID: PMC6724775

Genes

MBP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Truncated prion protein and Doppel are myelinotoxic in the absence of oligodendrocytic PrPC.PMID 15888663Read ↗

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