Article
Age-dependent motor deficits and dopaminergic dysfunction in DJ-1 null mice.
The Journal of biological chemistry - 3 Jun 2005
Chen Linan, Cagniard Barbara, Mathews Tiffany, Jones Sara, Koh Hyun Chul, Ding Yunmin, Carvey Paul M, Ling Zaodung, Kang Un Jung, Zhuang Xiaoxi
Abstract excerpt
Mutations in the DJ-1 gene were recently identified in an autosomal recessive form of early-onset familial Parkinson disease. Structural biology, biochemistry, and cell biology studies have suggested potential functions of DJ-1 in oxidative stress, protein folding, and degradation pathways. However, animal models are needed to determine whether and how loss of DJ-1 function leads to Parkinson disease. We have...
Topics
- Age Factors
- Aging
- Animals
- Blotting, Western
- Brain
- Chromatography, High Pressure Liquid
- Disease Models, Animal
- Dopamine
- Electrochemistry
- Female
- Gene Targeting
- Genotype
- Immunohistochemistry
- Male