Article
Bcl-2 overexpression delays caspase-3 activation and rescues cerebellar degeneration in prion-deficient mice that overexpress amino-terminally truncated prion.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Oct 2007
Nicolas Oriol, Gavín Rosalina, Braun Nathalie, Ureña Jesús Mariano, Fontana Xavier, Soriano Eduardo, Aguzzi Adriano, del Río José Antonio
Abstract excerpt
Prnp knockout mice that overexpress an amino-truncated form of PrPc (deltaPrP) are ataxic and display cerebellar cell loss and premature death. Studies on the molecular and intracellular events that trigger cell death in these mutants may contribute to elucidate the functions of PrPc and to the design of treatments for prion disease. Here we examined the effects of Bcl-2 overexpression in neurons on the...
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