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Article

HIV-1 infection in individuals with the CCR5-Delta32/Delta32 genotype: acquisition of syncytium-inducing virus at seroconversion.

Journal of acquired immune deficiency syndromes (1999) - 1 Mar 2002

Sheppard Haynes W, Celum Connie, Michael Nelson L, O'Brien Stephen, Dean Michael, Carrington Mary, Dondero Dale, Buchbinder Susan P

Abstract excerpt

Homozygosity for the 32 base-pair deletion (Delta32/Delta32) in the CCR5 coreceptor gene is associated with incomplete HIV-1 resistance. Six HIV-1-infected Delta32/Delta32 patients have been reported. We report 2 additional Delta32/Delta32-infected individuals, among 106 seroconverters in a vaccine preparedness study. Like the previous 6, these individuals experienced rapid CD4 decline. However, taken together,...

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Source

Identifiers

PMID: 11873082
DOI: 10.1097/00126334-200203010-00013

Genes

CCR5
CXCR4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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HIV-1 infection in individuals with the CCR5-Delta32/Delta32 genotype: acquisition of syncytium-inducing virus at seroconversion.PMID 11873082Read ↗

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MT-2 tropism and CCR-5 genotype strongly influence disease progression in HIV-1-infected individuals.Semantic proximity Read ↗

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