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Article

HLA-A*24 is an independent predictor of 5-year progression to diabetes in autoantibody-positive first-degree relatives of type 1 diabetic patients.

Diabetes - 1 Apr 2013

Mbunwe Eric, Van der Auwera Bart J, Vermeulen Ilse, Demeester Simke, Van Dalem Annelien, Balti Eric V, Van Aken Sara, Derdelinckx Luc, Dorchy Harry, De Schepper Jean, van Schravendijk Chris, Wenzlau Janet M, Hutton John C, Pipeleers Daniël, Weets Ilse, Gorus Frans K

Abstract excerpt

We investigated whether HLA-A*24 typing complements screening for HLA-DQ and for antibodies (Abs) against insulin, GAD, IA-2 (IA-2A), and zinc transporter-8 (ZnT8A) for prediction of rapid progression to type 1 diabetes (T1D). Persistently Ab(+) siblings/offspring (n = 288; aged 0-39 years) of T1D patients were genotyped for HLA-DQA1-DQB1 and HLA-A*24 and monitored for development of diabetes within 5 years of...

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Identifiers

PMID: 23160529
DOI: 10.2337/db12-0747
PMCID: PMC3609594

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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