HLA-DQB1*0602 is associated with dominant protection from diabetes even among islet cell antibody-positive first-degree relatives of patients with IDDM.

doi:10.2337/diab.44.6.608

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Article

HLA-DQB1*0602 is associated with dominant protection from diabetes even among islet cell antibody-positive first-degree relatives of patients with IDDM.

Diabetes - 1 Jun 1995

Pugliese A, Gianani R, Moromisato R, Awdeh Z L, Alper C A, Erlich H A, Jackson R A, Eisenbarth G S

Abstract excerpt

HLA-DQB1 alleles confer susceptibility and resistance to insulin-dependent diabetes mellitus (IDDM). We investigated whether the susceptibility alleles DQB1*0302 and DQB1*0201 affect progression to diabetes among islet cell antibody-positive (ICA+) first-degree relatives of IDDM patients and whether the protective allele DQB1*0602 can be found and is still protective among such relatives. We human leukocyte...

Topics

Adolescent
Adult
Alleles
Autoantibodies
Child
Child, Preschool
Diabetes Mellitus, Type 1
Family
Female
Gene Frequency
Genes, Dominant

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Genotype

HLA-DQ Antigens

HLA-DQ beta-Chains

Humans

Islets of Langerhans

Life Tables

Male

Source

Open in PubMed

Identifiers

PMID: 7789622
DOI: 10.2337/diab.44.6.608

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7789622-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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HLA-DQB1*0602 is associated with dominant protection from diabetes even among islet cell antibody-positive first-degree relatives of patients with IDDM.PMID 7789622Read ↗

Sequence analysis of the diabetes-protective human leukocyte antigen-DQB1*0602 allele in unaffected, islet cell antibody-positive first degree relatives and in rare patients with type 1 diabetes.Semantic proximity Read ↗

Identification of prediabetes in first-degree relatives at intermediate risk of type I diabetes.Semantic proximity Read ↗

Limited loss of tolerance to islet autoantigens in ICA+ first degree relatives of patients with type I diabetes expressing the HLA dqb1*0602 allele.Semantic proximity Read ↗

HLA-DRB1*0403 is associated with dominant protection against IDDM in the general Dutch population and subjects with high-risk DQA1*0301-DQB1*0302/DQA1*0501-DQB1*0201 genotype.Semantic proximity Read ↗

Analysis of families at risk for insulin-dependent diabetes mellitus reveals that HLA antigens influence progression to clinical disease.Semantic proximity Read ↗

HLA-DRB1*15:01-DQA1*01:02-DQB1*06:02 Haplotype Protects Autoantibody-Positive Relatives From Type 1 Diabetes Throughout the Stages of Disease Progression.Semantic proximity Read ↗

ICA+ relatives with DQA1*0102/DQB1*0602 have expected 0602 sequence and DR types.Semantic proximity Read ↗

DRB1*0403 protects against IDDM in Caucasians with the high-risk heterozygous DQA1*0301-DQB1*0302/DQA1*0501-DQB1*0201 genotype. Belgian Diabetes Registry.Semantic proximity Read ↗

Combined positivity for HLA DQ2/DQ8 and IA-2 antibodies defines population at high risk of developing type 1 diabetes.Semantic proximity Read ↗

HLA Class II (DR, DQ, DP) Genes Were Separately Associated With the Progression From Seroconversion to Onset of Type 1 Diabetes Among Participants in Two Diabetes Prevention Trials (DPT-1 and TN07).Semantic proximity Read ↗

Interactions of age, islet cell antibodies, insulin autoantibodies, and first-phase insulin response in predicting risk of progression to IDDM in ICA+ relatives: the ICARUS data set. Islet Cell Antibody Register Users StudySemantic proximity Read ↗

Insulin and islet cell autoantibodies as time-dependent covariates in the development of insulin-dependent diabetes: a prospective study in relatives.Semantic proximity Read ↗

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