Article
Prediabetes in children: natural history, diagnosis, and preventive strategies.
Paediatric drugs - 1 Jan 2003
Kulmala Petri
Abstract excerpt
The clinical manifestation of type 1 diabetes mellitus is preceded by an asymptomatic prodromal period called prediabetes or preclinical diabetes. It may last from a few months to several years, during which the autoimmune destruction of the insulin-producing beta-cells in the pancreas progresses. The genes on the human leukocyte antigen (HLA) and insulin gene region are major genetic determinants for genetic...
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