Article
Association between cyclosporine concentration and genetic polymorphisms of CYP3A5 and MDR1 during the early stage after renal transplantation.
Experimental and clinical transplantation : official journal of the Middle East Society for Organ Transplantation - 1 Jun 2006
Azarpira N, Aghdaie M H, Behzad-Behbahanie A, Geramizadeh B, Behzadi S, Malekhoseinie S A, Raisjalal G H, Rahsaz M, Pourgholami A, Sagheb F
Abstract excerpt
OBJECTIVES: Cyclosporine (CsA) has a narrow therapeutic range, and its pharmacokinetic characteristics vary among individuals. It also is a substrate for cytochrome P450 (CYP) 3A and P-glycoprotein, the product of the multidrug resistance 1 (MDR1) and CYP3A5 genes. Some of the single nucleotide polymorphisms (SNPs) in these genes are associated with deficient protein expression and reduced in vivo activity. We...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.