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Article

Explaining variability in ciclosporin exposure in adult kidney transplant recipients.

European journal of clinical pharmacology - 1 Jun 2010

Press Rogier R, Ploeger Bart A, den Hartigh Jan, van der Straaten T, van Pelt Hans, Danhof Meindert, de Fijter Hans, Guchelaar Henk-Jan

Abstract excerpt

PURPOSE: Optimal ciclosporin A (CsA) exposure in kidney transplant recipients is difficult to attain because of variability in CsA pharmacokinetics. A better understanding of the variability in CsA exposure could be a good means of individualizing therapy. Specifically, genetic variability in genes involved in CsA metabolism could explain exposure differences. Therefore, this study is aimed at identifying a...

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Identifiers

PMID: 20354687
DOI: 10.1007/s00228-010-0810-9
PMCID: PMC2868991

Genes

ABCB1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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