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Article

MDR-1 C3435T polymorphism influences cyclosporine a dose requirement in liver-transplant recipients.

Transplantation - 15 Jul 2004

Bonhomme-Faivre Laurence, Devocelle Aurore, Saliba Faouzi, Chatled Skander, Maccario Jean, Farinotti Robert, Picard Véronique

Abstract excerpt

BACKGROUND: Cyclosporine A (CsA) is characterized by high interindividual variations in oral bioavailability and a narrow therapeutic index. CsA is a substrate for P-glycoprotein, a member of the ABC transporter family encoded by the multiple drug-resistant gene MDR1. METHODS: Because MDR1 gene exon 26 C3435T polymorphism influences intestinal P-glycoprotein expression, we investigated whether this polymorphism...

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Share to ATP Binding Cassette Transporter, Subfamily B, Member 1
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 15257034
DOI: 10.1097/01.tp.0000130981.55654.78

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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MDR-1 C3435T polymorphism influences cyclosporine a dose requirement in liver-transplant recipients.PMID 15257034Read ↗

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