Article
Amlodipine, but not MDR1 polymorphisms, alters the pharmacokinetics of cyclosporine A in Japanese kidney transplant recipients.
Transplantation - 15 Sept 2003
Kuzuya Takafumi, Kobayashi Takaaki, Moriyama Natsuko, Nagasaka Takaharu, Yokoyama Itsuo, Uchida Kazuharu, Nakao Akimasa, Nabeshima Toshitaka
Abstract excerpt
BACKGROUND: Cyclosporine A (CsA) is a critical immunosuppressive drug with a narrow therapeutic range and wide interindividual variation in its pharmacokinetics. Many factors, including P-glycoprotein (PGP), influence the oral bioavailability and interpatient variability of CsA. A number of polymorphisms have been identified in the human MDR1 gene, and some of them have been found to be associated with an altered...
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