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Article

COMT val158Met and executive control: a test of the benefit of specific deficits to translational research.

Journal of abnormal psychology - 1 May 2007

MacDonald Angus W, Carter Cameron S, Flory Janine D, Ferrell Robert E, Manuck Stephen B

Abstract excerpt

The role of catechol-O-methyltransferase (COMT) val158met in prefrontal cortical deficits associated with the liability to schizophrenia remains controversial. This study evaluated 464 healthy adult participants using three measures of executive functions in working memory: a 3-back version of the N-back continuous performance task (CPT) and two variants of the AX-CPT. The interpretability of N-back performance...

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Source

Identifiers

PMID: 17516763
DOI: 10.1037/0021-843X.116.2.306

Genes

COMT

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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COMT val158Met and executive control: a test of the benefit of specific deficits to translational research.PMID 17516763Read ↗

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Executive attention in schizophrenic males and the impact of COMT Val108/158Met genotype on performance on the attention network test.Semantic proximity Read ↗

Effects of the catechol-O-methyltransferase Val158Met polymorphism on executive function: a meta-analysis of the Wisconsin Card Sort Test in schizophrenia and healthy controls.Semantic proximity Read ↗

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