Afr1p has a role in regulating the localization of Mpk1p at the shmoo tip in Saccharomyces cerevisiae.

doi:10.1016/j.febslet.2007.05.011

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Article

Afr1p has a role in regulating the localization of Mpk1p at the shmoo tip in Saccharomyces cerevisiae.

FEBS letters - 12 Jun 2007

Changwei Zhu, Mingyong Xiong, Ranran Wen

Abstract excerpt

Afr1p functions to promote adaptation to pheromone-induced growth arrest and morphogenesis. We show here that Afr1p regulates polarized localization of the Mpk1p MAP kinase in shmooing cells. Deletion of AFR1 results in mislocalization of Mpk1p although the scaffold protein Spa2p localizes normally at shmoo tip, and overexpression of Spa2 cannot rescue this defect, indicating Afr1p in required for Spa2p to...

Topics

Cytoskeletal Proteins
Green Fluorescent Proteins
Microscopy, Fluorescence
Mitogen-Activated Protein Kinases
Mutation
Saccharomyces cerevisiae
Saccharomyces cerevisiae Proteins

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Identifiers

PMID: 17509572
DOI: 10.1016/j.febslet.2007.05.011

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