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Article

AFR1 promotes polarized apical morphogenesis in Saccharomyces cerevisiae.

Molecular and cellular biology - 1 Feb 1995

Konopka J B, DeMattei C, Davis C

Abstract excerpt

The G protein-coupled alpha-factor receptor promotes polarized growth toward a mating partner. alpha-Factor induces the expression of AFR1, which acts together with the receptor C terminus to promote normal morphogenesis. The function of AFR1 was investigated by engineering cells to constitutivel...

Topics

Blotting, Western
Cell Cycle Proteins
Fungal Proteins
GTP Phosphohydrolases
Gene Expression
Genes, Fungal
Genotype
Mating Factor
Membrane Proteins
Morphogenesis
Mutagenesis
Peptides
Phenotype

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Pheromones

Profilins

Saccharomyces cerevisiae

Saccharomyces cerevisiae Proteins

Schizosaccharomyces pombe Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 7823940
DOI: 10.1128/MCB.15.2.723
PMCID: PMC231939

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7823940-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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AFR1 promotes polarized apical morphogenesis in Saccharomyces cerevisiae.PMID 7823940Read ↗

AFR1 acts in conjunction with the alpha-factor receptor to promote morphogenesis and adaptation.Semantic proximity Read ↗

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A GTP-exchange factor required for cell orientation.Semantic proximity Read ↗

The role of Far1p in linking the heterotrimeric G protein to polarity establishment proteins during yeast mating.Semantic proximity Read ↗

Saccharomyces cerevisiae Afr1 protein is a protein phosphatase 1/Glc7-targeting subunit that regulates the septin cytoskeleton during mating.Semantic proximity Read ↗

FAR1 is required for oriented polarization of yeast cells in response to mating pheromones.Semantic proximity Read ↗

The Rsr1/Bud1 GTPase interacts with itself and the Cdc42 GTPase during bud-site selection and polarity establishment in budding yeast.Semantic proximity Read ↗

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Identification of the mgc1 mutation which affects mating-pheromone-induced morphogenesis in the yeast Saccharomyces cerevisiae.Semantic proximity Read ↗

The C terminus of the Saccharomyces cerevisiae alpha-factor receptor contributes to the formation of preactivation complexes with its cognate G protein.Semantic proximity Read ↗

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