Site-specific regulation of the GEF Cdc24p by the scaffold protein Far1p during yeast mating.

doi:10.1038/sj.emboj.7600123

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Article

Site-specific regulation of the GEF Cdc24p by the scaffold protein Far1p during yeast mating.

The EMBO journal - 10 Mar 2004

Wiget Philippe, Shimada Yukiko, Butty Anne-Christine, Bi Efrei, Peter Matthias

Abstract excerpt

Receptor-mediated cell polarization via heterotrimeric G-proteins induces cytoskeletal rearrangements in a variety of organisms. In yeast, Far1p is required for orienting cell growth towards the mating partner by linking activated Gbetagamma to the guanine-nucleotide exchange factor (GEF) Cdc24p, which activates the Rho-type GTPase Cdc42p. Here we investigated the role of Far1p in the regulation of Cdc24p in...

Topics

Amino Acid Sequence
Cell Cycle Proteins
Cell Membrane
Cell Polarity
Cyclin-Dependent Kinase Inhibitor Proteins
Dimerization
Diploidy
GTP-Binding Protein beta Subunits
GTP-Binding Protein gamma Subunits
Gene Expression Regulation, Fungal
Guanine Nucleotide Exchange Factors
Molecular Sequence Data

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Pheromones

Protein Structure, Tertiary

Repressor Proteins

Saccharomyces cerevisiae

Saccharomyces cerevisiae Proteins

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Identifiers

PMID: 14988725
DOI: 10.1038/sj.emboj.7600123
PMCID: PMC380978

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