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Article

Counteractive control of polarized morphogenesis during mating by mitogen-activated protein kinase Fus3 and G1 cyclin-dependent kinase.

Molecular biology of the cell - 1 Apr 2008

Yu Lu, Qi Maosong, Sheff Mark A, Elion Elaine A

Abstract excerpt

Cell polarization in response to external cues is critical to many eukaryotic cells. During pheromone-induced mating in Saccharomyces cerevisiae, the mitogen-activated protein kinase (MAPK) Fus3 induces polarization of the actin cytoskeleton toward a landmark generated by the pheromone receptor. Here, we analyze the role of Fus3 activation and cell cycle arrest in mating morphogenesis. The MAPK scaffold Ste5 is...

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Identifiers

PMID: 18256288
DOI: 10.1091/mbc.e07-08-0757
PMCID: PMC2291402

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Counteractive control of polarized morphogenesis during mating by mitogen-activated protein kinase Fus3 and G1 cyclin-dependent kinase.PMID 18256288Read ↗

Pheromone-induced polarization is dependent on the Fus3p MAPK acting through the formin Bni1p.Semantic proximity Read ↗

Fus1p interacts with components of the Hog1p mitogen-activated protein kinase and Cdc42p morphogenesis signaling pathways to control cell fusion during yeast mating.Semantic proximity Read ↗

Identification of genes required for normal pheromone-induced cell polarization in Saccharomyces cerevisiae.Semantic proximity Read ↗

Regulation of polarized growth initiation and termination cycles by the polarisome and Cdc42 regulators.Semantic proximity Read ↗

Dynamic localization of yeast Fus2p to an expanding ring at the cell fusion junction during mating.Semantic proximity Read ↗

The class V myosin Myo2p is required for Fus2p transport and actin polarization during the yeast mating response.Semantic proximity Read ↗

Fus3p and Kss1p control G1 arrest in Saccharomyces cerevisiae through a balance of distinct arrest and proliferative functions that operate in parallel with Far1p.Semantic proximity Read ↗

Saccharomyces cerevisiae Ste5 is important for induction and substrate specificity of Fus3 MAP kinase in the pheromone signaling pathway.Semantic proximity Read ↗

Mitogen-activated protein kinase (MAPK) dynamics determine cell fate in the yeast mating response.Semantic proximity Read ↗

Pheromone response in yeast: association of Bem1p with proteins of the MAP kinase cascade and actin.Semantic proximity Read ↗

FUS3 encodes a cdc2+/CDC28-related kinase required for the transition from mitosis into conjugation.Semantic proximity Read ↗

Fus3-regulated Tec1 degradation through SCFCdc4 determines MAPK signaling specificity during mating in yeast.Semantic proximity Read ↗

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