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Article

MN1 overexpression induces acute myeloid leukemia in mice and predicts ATRA resistance in patients with AML

10 May 2007

Abstract excerpt

Overexpression of wild-type MN1 is a negative prognostic factor in patients with acute myeloid leukemia (AML) with normal cytogenetics. We evaluated whether MN1 plays a functional role in leukemogenesis. We demonstrate using retroviral gene transfer and bone marrow (BM) transplantation that MN1 overexpression rapidly induces lethal AML in mice. Insertional mutagenesis and chromosomal instability were ruled out as...

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PMID: 17494859
DOI: 10.1182/blood-2007-03-080523

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