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Maintaining the self-renewal and differentiation potential of human CD34+ hematopoietic cells using a single genetic element

2 Sept 2003

Abstract excerpt

Hematopoiesis is a complex process involving hematopoietic stem cell (HSC) self-renewal and lineage commitment decisions that must continue throughout life. Establishing a reproducible technique that allows for the long-term ex vivo expansion of human HSCs and maintains self-renewal and multipotential differentiation will allow us to better understand these processes, and we report the ability of the...

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PMID: 12946995
DOI: 10.1182/blood-2003-05-1762

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