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Article

Improved prediction of response to antiretroviral combination therapy using the genetic barrier to drug resistance.

Antiviral therapy - 1 Jan 2007

Altmann Andre, Beerenwinkel Niko, Sing Tobias, Savenkov Igor, Doumer Martin, Kaiser Rolf, Rhee Soo-Yon, Fessel W Jeffrey, Shafer Robert W, Lengauer Thomas

Abstract excerpt

BACKGROUND: The outcome of antiretroviral combination therapy depends on many factors involving host, virus, and drugs. We investigate prediction of treatment response from the applied drug combination and the genetic constellation of the virus population at baseline. The virus's evolutionary potential for escaping from drug pressure is explored as an additional predictor. METHODS: We compare different encodings...

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Identifiers

PMID: 17503659
DOI: 10.1177/135965350701200202

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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