Article
Genotypic predictors of human immunodeficiency virus type 1 drug resistance.
Proceedings of the National Academy of Sciences of the United States of America - 14 Nov 2006
Rhee Soo-Yon, Taylor Jonathan, Wadhera Gauhar, Ben-Hur Asa, Brutlag Douglas L, Shafer Robert W
Abstract excerpt
Understanding the genetic basis of HIV-1 drug resistance is essential to developing new antiretroviral drugs and optimizing the use of existing drugs. This understanding, however, is hampered by the large numbers of mutation patterns associated with cross-resistance within each antiretroviral drug class. We used five statistical learning methods (decision trees, neural networks, support vector regression,...
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