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Article

Geno2pheno: Estimating phenotypic drug resistance from HIV-1 genotypes.

Nucleic acids research - 1 Jul 2003

Beerenwinkel Niko, Däumer Martin, Oette Mark, Korn Klaus, Hoffmann Daniel, Kaiser Rolf, Lengauer Thomas, Selbig Joachim, Walter Hauke

Abstract excerpt

Therapeutic success of anti-HIV therapies is limited by the development of drug resistant viruses. These genetic variants display complex mutational patterns in their pol gene, which codes for protease and reverse transcriptase, the molecular targets of current antiretroviral therapy. Genotypic resistance testing depends on the ability to interpret such sequence data, whereas phenotypic resistance testing...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 12824435
DOI: 10.1093/nar/gkg575
PMCID: PMC168981

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