Article
Using drug exposure for predicting drug resistance - A data-driven genotypic interpretation tool.
PloS one - 1 Jan 2017
Pironti Alejandro, Pfeifer Nico, Walter Hauke, Jensen Björn-Erik O, Zazzi Maurizio, Gomes Perpétua, Kaiser Rolf, Lengauer Thomas
Abstract excerpt
Antiretroviral treatment history and past HIV-1 genotypes have been shown to be useful predictors for the success of antiretroviral therapy. However, this information may be unavailable or inaccurate, particularly for patients with multiple treatment lines often attending different clinics. We trained statistical models for predicting drug exposure from current HIV-1 genotype. These models were trained on 63,742...
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