Article
Selecting anti-HIV therapies based on a variety of genomic and clinical factors.
Bioinformatics (Oxford, England) - 1 Jul 2008
Rosen-Zvi Michal, Altmann Andre, Prosperi Mattia, Aharoni Ehud, Neuvirth Hani, Sönnerborg Anders, Schülter Eugen, Struck Daniel, Peres Yardena, Incardona Francesca, Kaiser Rolf, Zazzi Maurizio, Lengauer Thomas
Abstract excerpt
MOTIVATION: Optimizing HIV therapies is crucial since the virus rapidly develops mutations to evade drug pressure. Recent studies have shown that genotypic information might not be sufficient for the design of therapies and that other clinical and demographical factors may play a role in therapy failure. This study is designed to assess the improvement in prediction achieved when such information is taken into...
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