Article
The frequency and structure of recombinant products is determined by the cellular level of MutL.
Proceedings of the National Academy of Sciences of the United States of America - 22 May 2007
Elez Marina, Radman Miroslav, Matic Ivan
Abstract excerpt
The presence of repeated DNA sequences is a genomic liability, because interrepeat recombination can result in chromosomal rearrangements. The mismatch repair system prevents recombination between nonidentical repeats, but the mechanism of antirecombination has not been established. Although the MutS protein binds to base pair mismatches in heteroduplex DNA, the role of the MutL protein in preventing...
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